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1

Insulin resistance is associated with abnormal dephosphorylation of a synthetic phosphopeptide corresponding to the major autophosphorylation sites of the insulin receptor

Janet Sredy, Diane R. Sawicki, Brenda R. Flam, Donald Sullivan

Journal:

Year:

1995

Language:

english

File:

PDF, 875 KB

english, 1995

2

Structural abnormalities do not explain the early functional abnormalities in the peripheral nerves of the streptozotocin diabetic rat

DAVID WALKER, ANNE CARRINGTON, SUSAN A. CANNAN, DIANE SAWICKI, JANET SREDY, ANDREW J. M. BOULTON, RAYAZ A. MALIK

Journal:

Journal of Anatomy

Year:

1999

Language:

english

File:

PDF, 677 KB

english, 1999

3

ChemInform Abstract: Synthesis and PTP1B Inhibition of Novel 4-Aryl-1-oxa-9-thiacyclopenta[b]fluorenes.

Jay Wrobel, Zenan Li, Janet Sredy, Diane R. Sawicki, Laura Seestaller, Donald Sullivan

Journal:

Year:

2000

File:

PDF, 32 KB

2000

4

Emerging therapeutics for diabetic retinopathy: potential therapies for the new millennium

Jacot, Jorge L, Sredy, Janet

Journal:

Expert Opinion on Therapeutic Targets

Year:

1999

Language:

english

File:

PDF, 257 KB

english, 1999

5

Phosphorylated intermediates of two Ca ++ -ATPases in membrane preparations from lens epithelial cells

Chiesa, Raúl, Sredy, Janet, Spector, Abraham

Journal:

Current Eye Research

Year:

1985

Language:

english

File:

PDF, 761 KB

english, 1985

6

Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications

Michael C. Van Zandt, Brian Doan, Diane R. Sawicki, Janet Sredy, Alberto D. Podjarny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 378 KB

english, 2009

7

Vanadate as an oral antidiabetic agent

Sredy, Janet, Wrobel, Jay

Journal:

Expert Opinion on Investigational Drugs

Year:

1994

Language:

english

File:

PDF, 374 KB

english, 1994

8

Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole- N -acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications

Van Zandt, Michael C., Jones, Michael L., Gunn, David E., Geraci, Leo S., Jones, J. Howard, Sawicki, Diane R., Sredy, Janet, Jacot, Jorge L., DiCioccio, A. Thomas, Petrova, Tatiana, Mitschler, Andre,

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 338 KB

english, 2005

9

Computer assisted design and synthesis of novel aldose reductase inhibitors

Butera, John, Bagli, Jehan, Doubleday, Wendel, Humber, Leslie, Treasurywala, Adi, Loughney, Deborah, Sestanj, Kazimir, Millen, Jane, Sredy, Janet

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 3.76 MB

english, 1989

10

The phosphorylation of bovine and human lens polypeptides

Janet Sredy, Abraham Spector

Journal:

Experimental Eye Research

Year:

1984

Language:

english

File:

PDF, 2.51 MB

english, 1984

11

Novel Benzofuran and Benzothiophene Biphenyls as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties

Malamas, Michael S., Sredy, Janet, Moxham, Christopher, Katz, Alan, Xu, Weixin, McDevitt, Robert, Adebayo, Folake O., Sawicki, Diane R., Seestaller, Laura, Sullivan, Donald

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 1.06 MB

english, 2000

12

Synthesis and PTP1B Inhibition of Novel 4-Aryl-1-Oxa-9-Thiacyclopenta[b]fluorenes

Jay Wrobel, Zenan Li, Janet Sredy, Diane R Sawicki, Laura Seestaller, Donald Sullivan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 273 KB

english, 2000

13

Syntheses of tolrestat analogs containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives

Wrobel, Jay, Millen, Jane, Sredy, Janet, Dietrich, Arlene, Gorham, Beverly J., Malamas, Michael, Kelly, Joseph M., Bauman, John G., Harrison, Maria C.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 2.00 MB

english, 1991

14

ChemInform Abstract: Antihyperglycemic Activity of New 1,2,4-Oxadiazoline-3,5-diones.

Michael S. Malamas, Janet Sredy, Michael McCaleb, Iwan Gunawan, Brenda Mihan, Donald Sullivan

Journal:

Year:

2001

File:

PDF, 30 KB

2001

15

Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents

Wrobel, Jay, Dietrich, Arlene, Woolson, Shiela A., Millen, Jane, McCaleb, Michael, Harrison, Maria C., Hohman, Thomas C., Sredy, Janet, Sullivan, Donald

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.48 MB

english, 1992

16

Polyol pathway activity in nervous tissues of diabetic and galactose-fed rats: Effect of dietary galactose withdrawal or tolrestat intervention therapy

Sredy, Janet, Sawicki, Diane R., Notvest, Ronald R.

Journal:

Journal of Diabetic Complications

Year:

1991

Language:

english

File:

PDF, 707 KB

english, 1991

17

New Azolidinediones as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties

Malamas, Michael S., Sredy, Janet, Gunawan, Iwan, Mihan, Brenda, Sawicki, Diane R., Seestaller, Laura, Sullivan, Donald, Flam, Brenda R.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 273 KB

english, 2000

18

cAMP-Dependent Phosphorylation of Bovine Lens α -crystallin

Abraham Spector, Raul Chiesa, Janet Sredy and William Garner

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.28 MB

english, 1985

19

Phosphorylation of H2O2-treated lens Na+, K+-ATPase

Janet Sredy, Abraham Spector

Journal:

Experimental Eye Research

Year:

1984

Language:

english

File:

PDF, 675 KB

english, 1984

20

ChemInform Abstract: New Azolidinediones as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties.

Michael S. Malamas, Janet Sredy, Iwan Gunawan, Brenda Mihan, Diane R. Sawicki, Laura Seestaller, Donald Sullivan, Brenda R. Flam

Journal:

Year:

2000

File:

PDF, 35 KB

2000

21

Identification of two of the major phosphorylated polypeptides of the bovine lens utilizing a lens cAMP-dependent protein kinase system

Sredy, Janet, Roy, Debdutta, Spector, Abraham

Journal:

Current Eye Research

Year:

1984

Language:

english

File:

PDF, 863 KB

english, 1984

22

PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[ b ]naphtho[2,3- d ]furans and 11-Arylbenzo[ b ]naphtho[2,3- d ]thiophenes

Wrobel, Jay, Sredy, Janet, Moxham, Christopher, Dietrich, Arlene, Li, Zenan, Sawicki, Diane R., Seestaller, Laura, Wu, Li, Katz, Alan, Sullivan, Donald, Tio, Cesario, Zhang, Zhong-Yin

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 56 KB

english, 1999

23

Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat

McCaleb, Michael L., Sredy, Janet, Millen, Jane, Ackerman, Denis M., Dvornik, Dushan

Journal:

Journal of Diabetic Complications

Year:

1988

Language:

english

File:

PDF, 351 KB

english, 1988

24

Novel 5-(3-Aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones as Antihyperglycemic Agents

Wrobel, Jay, Li, Zenan, Dietrich, Arlene, McCaleb, Michael, Mihan, Brenda, Sredy, Janet, Sullivan, Donald

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 150 KB

english, 1998

25

Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications

Michael C. Van Zandt, Evelyn O. Sibley, Erin E. McCann, Kerry J. Combs, Brenda Flam, Diane R. Sawicki, Al Sabetta, Anne Carrington, Janet Sredy, Eduardo Howard, Andre Mitschler, Alberto D. Podjarny

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 436 KB

english, 2004

26

Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones

Michael S Malamas, Janet Sredy, Michael McCaleb, Iwan Gunawan, Brenda Mihan, Donald Sullivan

Journal:

European Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 174 KB

english, 2001

27

Orally active aldose reductase inhibitors derived from bioisosteric substitutions on tolrestat

Wrobel, Jay, Millen, Jane, Sredy, Janet, Dietrich, Arlene, Kelly, Joseph M., Gorham, Beverly J., Sestanj, Kazimir

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.13 MB

english, 1989

28

(Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors

Ellingboe, John, Alessi, Thomas, Millen, Jane, Sredy, Janet, King, Andrew, Prusiewicz, Candace, Guzzo, Frieda, VanEngen, Donna, Bagli, Jehan

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.10 MB

english, 1990

29

Metabolic abnormalities of the hyperglycemic obese Zucker rat

Michael L. McCaleb, Janet Sredy

Journal:

Year:

1992

Language:

english

File:

PDF, 480 KB

english, 1992

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